UGT1A1*28 allele and coronary heart disease: the Rotterdam Study.
نویسندگان
چکیده
Rotterdam Study, Piter J. Bosma, Irene M. van der Meer, Conny T. Bakker, Albert Hofman, Marianne Paul-Abrahamse, and Jacqueline C. Witteman ( Liver Center, Academic Medical Center, Meibergdreef 9, 1105AZ Amsterdam, The Netherlands; 2 Department of Epidemiology & Biostatistics, Erasmus MC, University Medical Center, Rotterdam, PO Box 1738, 3000DR Rotterdam, The Netherlands; * author for correspondence: fax 31-20-5669190, e-mail [email protected])
منابع مشابه
Association between the UGT1A1*28 allele, bilirubin levels, and coronary heart disease in the Framingham Heart Study.
BACKGROUND Bilirubin is an antioxidant that suppresses lipid oxidation and retards atherosclerosis formation. An inverse association between serum bilirubin and coronary heart disease has been reported. Linkage studies have identified a major locus at the chromosome 2q telomere that affects bilirubin concentrations. A candidate gene in the linkage region encodes hepatic bilirubin uridine diphos...
متن کاملUGT1A1 gene linkage analysis: application of polymorphic markers rs4148326/rs4124874 in the Iranian population
Objective(s): Mutations in the UGT1A1 gene are responsible for hyperbilirubinemia syndromes including Crigler-Najjar type 1 and 2 and Gilbert syndrome. In view of the genetic heterogeneity and involvement of large numbers of the disease causing mutations, the application of polymorphic markers in the UGTA1 gene could be useful in molecular diagnosis of the disease. Materials and Methods: In the...
متن کاملEvaluation of Apolipoprotein A5 Polymorphism in Coronary- Heart Disease Patients
Background and Objectives: Apolipoprotein A5 (APOA5) gene is important in determining plasma triglyceride levels, a major cardiovascular disease risk factor. Mutation in this gene affected plasma triglyceride level. We looked for possible associations of the APOA5 gene polymorphism S19W with coronary heart disease (CHD) in a sample of Iranian population. Materials and Methods: A total of 7...
متن کاملBilirubin concentration, UGT1A1*28 polymorphism, and coronary artery disease.
An inverse association between serum bilirubin and cardiovascular disease has been shown in numerous retrospective and prospective studies (1–8) as well as in a metaanalysis study (9 ). Schwertner et al. (1 ) first reported that fasting serum bilirubin concentrations are inversely related to coronary artery stenosis in men. Low serum bilirubin concentrations were found to be associated with an ...
متن کاملExtreme neonatal hyperbilirubinemia and a specific genotype: a population-based case-control study.
OBJECTIVES Extreme hyperbilirubinemia (plasma bilirubin ≥ 24.5 mg/dL) is an important risk factor for severe bilirubin encephalopathy. Several risk factors for hyperbilirubinemia are known, but in a large number of patients, a causal factor is never established. UGT1A1 is the rate-limiting enzyme in bilirubin's metabolism. The genotype of Gilbert syndrome, the UGT1A1*28 allele, causes markedly ...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Clinical chemistry
دوره 49 7 شماره
صفحات -
تاریخ انتشار 2003